Click chemistry 点击化学 链接化学
Click chemistry 点击化学 链接化学
点击化学工具:DBCO，TCO，四嗪，叠氮化物，炔烃和相关试剂。
DBCO Reagents
The dibenzocyclooctyne group (DBCO) allows Copper-free Click Chemistry to be done with live cells, whole organisms, and non-living samples.
DBCO-C6-NHS Ester DBCO-C6-NHS Ester is an amine-reactive building block used for modification of amine-containing molecule in organic media.
DBCO-NHS Ester DBCO-NHS Ester is an amine-reactive building block used for modification of amine-containing molecule in organic media.
DBCO-Sulfo-NHS Ester DBCO-Sulfo-NHS Ester is water-soluble reagent that enables simple and efficient labeling of antibodies, proteins and any other primary amine-containing macromolecules with DBCO moiety in aqueous buffers.
DBCO-PEG4-NHS Ester DBCO-PEG4-NHS Ester reacts specifically and efficiently with a primary amine (e.g., side chain of lysine residues or aminosilane-coated surfaces) at pH 7-9 to form a covalent bond.
DBCO-PEG5-NHS Ester DBCO-PEG5-NHS Ester reacts specifically and efficiently with a primary amine (e.g., side chain of lysine residues or aminosilane-coated surfaces) at pH 7-9 to form a covalent bond.
DBCO-PEG13-NHS Ester DBCO-PEG13-NHS Ester reacts specifically and efficiently with a primary amine (e.g., side chain of lysine residues or aminosilane-coated surfaces) at pH 7-9 to form a covalent bond. The hydrophilic polyethylene glycol (PEG) spacer arm imparts water solubility and provides a long and flexible connection that minimizes steric hindrance involved with ligation to complementary azide-containing molecules.
PC DBCO-NHS Ester Photocleavable DBCO-NHS ester reagent contains an amine reactive group linked to DBCO moiety through a spacer arm containing a photocleavable moiety.
DBCO-C6-Acid DBCO-C6-Acid is an analog of DBCO-Acid with extended 6-carbon atom spacer arm.
DBCO-Acid DBCO-Acid is an amine-reactive non-activated building block used for derivatizing amine-containing molecule in the presence of activators (e.g. EDC, or HATU) through a stable amide bond.
DBCO-PEG5-Acid DBCO-PEG5-Acid is an amine-reactive, non-activated building block with enhanced solubility in aqueous media used for derivatizing amine-containing molecule in the presence of activators (e.g. EDC, or HATU) through a stable amide bond.
DBCO-Amine DBCO-Amine is a simple DBCO-containing building block used to derivatize carboxyl groups in the presence of activators (e.g. EDC, or DCC) or activated esters (e.g. NHS esters) with DBCO moiety through a stable amide bond.
DBCO-PEG3-Amine DBCO-PEG3-Amine is a carboxyl-reactive building block with enhanced solubility in aqueous media used to derivatize carboxyl groups in the presence of activators (e.g. EDC, or DCC) or activated esters (e.g. NHS esters) through a stable amide bond.
Sulfo DBCO-Amine Sulfo DBCO-Amine is a water-soluble building block used to derivatize carboxyl-containing molecules or activated esters (e.g. NHS esters) with DBCO moiety through a stable amide bond. The hydrophilic sulfonated spacer arm greatly improves water solubility of DBCO derivatized molecules, in many cases making it completely soluble in aqueous media.
Sulfo DBCO-PEG4-Amine Sulfo DBCO-PEG4-Amine is a water-soluble reagent used to derivatize carboxyl-containing molecules or activated esters (e.g. NHS esters) with DBCO moiety through a stable amide bond.
DBCO-Maleimide DBCO-Maleimide enables simple and efficient incorporation of DBCO moiety onto cysteine-containing peptides or other thiol-containing molecules.
DBCO-PEG4-Maleimide DBCO-PEG4-Maleimide enables simple and efficient incorporation of DBCO moiety onto antibodies, cysteine-containing peptides and other thiol-containing molecules.
Bis-sulfone-PEG4-DBCO Bis-sulfone-PEG4-DBCO is a bis-alkylating labeling reagent that enables site-specific incorporation of DBCO moiety onto antibodies to form well-defined conjugates.
ThioLinker-DBCO ThioLinkerTM-DCBO is a water-soluble bis-alkylating labeling reagent enables site-specific incorporation of DBCO moiety onto antibodies in well-defined fashion.
MB 488 DBCO MB™ 488 DBCO is a bright, green fluorescent probe with excitation ideally suited for the 488 nm laser line.
MB 543 DBCO MB™ 543 DBCO is an orange colored fluorescent probe with absorption and emission maxima at 544 and 560 nm, respectively.
MB 594 DBCO MB™ 594 is a bright, red fluorescent probe with absorption and emission maxima similar to Texas Red dye or Alexa Fluor 594®.
Carboxyrhodamine 110 DBCO Carboxyrhodamine110 DBCO dye reacts with azides via a copper-free “click chemistry” reaction to form a stable triazole and does not require Cu-catalyst or elevated temperatures.
TAMRA DBCO TAMRA DBCO dye reacts with azides via a copper-free “click chemistry” reaction to form a stable triazole and does not require Cu-catalyst or elevated temperatures.
Cy3 DBCO Cy3 DBCO dye reacts with azides via a copper-free “click chemistry” reaction to form a stable triazole and does not require Cu-catalyst or elevated temperatures.
Cy5 DBCO Cy5 DBCO dye reacts with azides via a copper-free “click chemistry” reaction to form a stable triazole and does not require Cu-catalyst or elevated temperatures.
Cy5.5 DBCO Cy5.5 DBCO dye reacts with azides via a copper-free “click chemistry” reaction to form a stable triazole and does not require Cu-catalyst or elevated temperatures.
Cy7 DBCO Cy7 DBCO dye reacts with azides via a copper-free “click chemistry” reaction to form a stable triazole and does not require Cu-catalyst or elevated temperatures.
DBCO-PEG4-Biotin DBCO-PEG4-Biotin reacts with azides via a copper-free “click chemistry” reaction to form a stable triazole and does not require Cu-catalyst or elevated temperatures.
WS DBCO-Biotin A water-soluble, azide-reactive biotinylation reagent WS DBCO-Bitoin reacts with azides via a copper-free “click chemistry” reaction to form a stable triazole.
DBCO-PEG4-Desthiobiotin Desthiobiotin is a single-ring, sulfur-free analog of biotin that binds to streptavidin with nearly equal specificity but less affinity than biotin (Kd = 1011 vs. 1015M, respectively).
Dde Biotin-DBCO Dde Biotin-DBCO is an azide-reactive biotin probe that allows for efficient release of the captured biomolecules from streptavidin.
PC DBCO-Biotin PC Biotin-DBCO is an azide-reactive photoclevable biotin probe that allows for reagent-free release of the captured biomolecules from streptavidin.
WS-PC DBCO-Biotin WS-PC Biotin-DBCO is water soluble, azide-reactive photoclevable biotin probe that allows for reagent-free release of the captured biomolecules from streptavidin.
Diazo Biotin-DBCO Diazo Biotin-DBCO contains a biotin moiety linked to an DBCO group through a sodium dithionite (Na2S2O4) cleavable diazo linker.
DBCO-mPEG, 5 kDa DBCO-activated PEGylation reagents react with azides via a copper-free “click chemistry” reaction to form a stable triazole and does not require Cu-catalyst or elevated temperatures
DBCO-mPEG, 10 kDa DBCO-activated PEGylation reagents react with azides via a copper-free “click chemistry” reaction to form a stable triazole and does not require Cu-catalyst or elevated temperatures.
DBCO-mPEG, 20 kDa DBCO-activated PEGylation reagents react with azides via a copper-free “click chemistry” reaction to form a stable triazole and does not require Cu-catalyst or elevated temperatures.
DBCO-mPEG, 30 kDa DBCO-activated PEGylation reagents react with azides via a copper-free “click chemistry” reaction to form a stable triazole and does not require Cu-catalyst or elevated temperatures.
DBCO-PEG12-MMAE DBCO-containing auristatin drug used to create antibody-drug conjugates via SPAAC reaction.
Methyltetrazine-DBCO Heterobifunctional reagents used for converting azido-containing peptides or protein into tetrazine-modified peptides or protein without the need for catalyst or axillary reagents.
Methyltetrazine-PEG12-DBCO Heterobifunctional reagents used for converting azido-containing peptides or protein into tetrazine-modified peptides or protein without the need for catalyst or axillary reagents.
DBCO-PEG4-DBCO DBCO-PEG4-DBCO is a homobifunctional azide-to-azide cross-linker.
TCO-PEG12-DBCO Heterobifunctional reagents are used for converting azido-containing biomolecules into TCO-modified biomolecules.
DBCO-PEG4-Hydroxyl A modification reagent containing a long 4-unit polyethylene glycol (PEG4) spacer arm and a terminal primary hydroxyl group.
Tetrazine Reagents
Tetrazine-containing reagents are suitable for the introduction of a functional group (e.g. Amine or NHS Ester) to Cyclooctene-labeled molecules via Cu-free Click Chemistry an Tetrazine group to vario
Tetrazine-NHS Ester An amine-reactive building block with exceptional kinetics.
Methyltetrazine-NHS Ester An amine-reactive building block
Tetrazine-Sulfo-NHS Ester A water-soluble reagent for labeling antibodies, proteins and other molecules containing primary amines.
Methyltetrazine-Sulfo-NHS Ester A water-soluble amine-reactive labeling reagent
Tetrazine-PEG5-NHS Ester An amine-reactive labeling reagents with enhanced reactivity and water solubility.
Methyltetrazine-PEG4-NHS Ester An amine-reactive labeling reagents with enhanced stability and water solubility
Methyltetrazine-PEG5-NHS Ester An amine-reactive labeling reagent with hydrophilic PEG5 spacer arm
Methyltetrazine-PEG4-Sulfo-NHS Ester A water-soluble reagent for labeling antibodies, proteins and other molecules containing primary amines
Methyltetrazine-Acid An amine-reactive, non-activated building block.
Tetrazine-Acid An amine-reactive, non-activated building block with exceptional kinetics.
Methyltetrazine-PEG4-Acid An amine-reactive, non-activated building block with enhanced stability and water solubility.
PC Methyltetrazine-NHS Ester An amine-reactive, photocleavable labeling reagent.
Methyltetrazine-Amine A carboxyl-reactive building block containing tetrazine moiety.
Tetrazine-Amine A carboxyl-reactive building block with exceptional kinetics.
Methyltetrazine-Propylamine A carboxyl-reactive building block with enhanced stability.
Methyltetrazine-PEG4-Amine A carboxyl-reactive building block with enhanced stability and water solubility.
Methyltetrazine-PEG4-Maleimide A mid-length, sulfhydryl-reactive labeling reagent with enhanced water-solubility provided by a PEG4 spacer.
Bis-sulfone-PEG4-Tetrazine A bis-alkylating reagent used to introduce tetrazine moiety onto antibody in well-defined fashion.
ThioLinker-Tetrazine A water-soluble, thiol-reactive, bis-alkylating labeling reagent.
Methyltetrazine-DBCO A water-soluble azide-to-TCO heterobifunctional crosslinker
Methyltetrazine-PEG12-DBCO An azide-to-TCO heterobifunctional crosslinker with a hydrophilic PEG12 spacer arm
Methyltetrazine-PEG4-Alkyne Heterobifunctional reagent activated with terminal alkyne group and methyltetrazine moiety.
Methyltetrazine-PEG4-Azide An alkyne-to-TCO heterobifunctional crosslinker with a hydrophilic PEG4 spacer arm.
Methyltetrazine-mPEG, 5 kDa 5 kDa, methyltetrazine-activated PEGylation reagent.
Methyltetrazine-mPEG, 10 kDa 10 kDa, methyltetrazine-activated PEGylation reagent.
Methyltetrazine-mPEG, 20 kDa 20 kDa, Methyltetrazine-activated PEGylation reagent.
Methyltetrazine-mPEG, 30 kDa 30 kDa, Methyltetrazine-activated PEGylation reagent.
Biotin-PEG4-Methyltetrazine A methyltetrazine-activated biotinylation reagent with a hydrophilic PEG4 spacer arm.
Cy3 Tetrazine A tetrazine-activated Cy5 dye.
Cy3 Methyltetrazine A methyltetrazine-activated Cy3 dye for chemoselective labeling and detection of TCO-tagged molecules.
TAMRA Tetrazine An orange-to-red fluorescence-emitting, tetrazine-activated probe.
TAMRA Methyltetrazine An orange-to-red fluorescence-emitting, methyltetrazine-activated probe.
Cy5 Tetrazine A tetrazine-activated Cy5 dye.
Cy5 Methyltetrazine A methyltetrazine-activated Cy5 dye for chemoselective labeling and detection of TCO-tagged molecules.
Cy7 Methyltetrazine A water-soluble, tetrazine-activated NIR probe.
Tetrazine-PEG4-NOTA
MPEG-Tetrazine甲氧基聚乙二醇-四嗪磺基 MPEG-Tetrazine甲氧基聚乙二醇-四嗪磺基是YARE-PEG旗下高质量产品
Azide Reagents
Azido-containing building blocks, labeling reagents, haptens, and fluorescent probes
PC Biotin-Azide An azide-activated photoclevable biotin probe.
PC Azido-NHS Ester An amine-reactive, photocleavable labeling reagent.
Azido-Propylamine A carboxyl-reactive building block.
Alkyne Reagents
Alkyne-based labeling reagents, fluorescent probes and haptens for Cu-catalyzed click chemistry
Propargyl-NHS Ester An amine-reactive building block.
PC Alkyne-NHS Ester An amine-reactive, photocleavable labeling reagent.
Propargyl-Maleimide A maleimide-activated, building block.
PC Biotin-Alkyne An azide-activated photoclevable biotin probe
Dde Biotin-Alkyne An azide-reactive, hydrazine-cleavable biotin probe.
Diol Biotin-Alkyne An azide-reactive, sodium periodate cleavable biotin probe.
Diazo Biotin-Alkyne An azide-reactive, sodium dithionite cleavable biotinylation reagent.
Alkyne -PEG-Alkyne炔烃-聚乙二醇-炔烃 Alkyne -PEG-Alkyne炔烃-聚乙二醇-炔烃是YARE-PEG旗下高质量产品
TCO Reagents
Trans-Cyclooctene (TCO)-based labeling reagents, building blocks, and crosslinkers
TCO-NHS Ester An amine-reactive, succinimidyl carbonate/NHS functionalized cyclooctene building block
TCO-PNB Ester An amine-reactive, cyclooctene-containing building block.
TCO-PEG4-NHS Ester An amine-reactive labeling reagents with enhanced solubility in aqueous buffers
TCO-PEG12-NHS Ester Amine-reactive labeling reagents with extended PEG12 spacer arm
TCO-PEG4-Acid Amine-reactive, non-activated building block with enhanced solubility in aqueous buffers
TCO-PEG3-Maleimide A sulfhydryl-reactive labeling reagent with hydrophilic PEG4 spacer arm.
Cy5-TCO A TCO-activated Cy5 dye.
TCO-Amine HCl Salt A carboxyl-reactive building block.
TCO-PEG3-Amine A carbonyl-reactive building block with enhanced solubility in aqueous media.
TCO-PEG12-DBCO An azide-to-tetrazine heterobifunctional cross-linker with a hydrophilic PEG12 spacer arm
MPEG-TCO Methoxypolyethylene glycol-Total Cost of Ownership MPEG-TCO
Click chemistry 点击化学 链接化学
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Click chemistry 点击化学 链接化学
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